来源:必赢76net线路2021-10-25浏览次数:18490

韩晓冬

博士研究生导师简介

姓名

韩晓冬

研究方向

1生殖与发育

2环境污染与疾病发生

3干细胞与组织再生

联系方式

电话025-83686497

Email: hanxd@nju.edu.cn

学术兼职:

教育部高等学校基础医学类专业教学指导委员会委员

江苏省解剖学会理事长

《中华男科学杂志》 编委

个人简介

组织胚胎学教授,博士生导师。1984年毕业于南京老员工物系,获学士学位;1987年于南京老员工物系获硕士学位;2004年于南京老员工命科学院获博士学位。2001年,作为高级访问学者赴美国哈佛大学必赢76net线路Beth Israel Deaconess Medical Center开展合作研究。长期从事生殖与发育、环境污染与疾病发生、干细胞与组织再生研究,主持并参与国家自然科学基金、国家973计划、教育部博士点基金、江苏省自然科学基金等研究项目,在国内外学术刊物共发表论文210余篇。参编《组织胚胎学》、《生殖病理学》教材。讲的组织学与胚胎学”入选必赢76net线路百门优质课程,被认定为省级一流本科课程

承担科研项目[项目负责人]

  1. 国家自然科学基金项目(31870492):微囊藻毒素长期低剂量暴露引起小鼠学习记忆能力减退的分子机制探讨

  2. 国家自然科学基金项目(81570059):Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究

  3. 国家自然科学基金项目(31370524):微囊藻毒素下调雄性大鼠雄激素(睾酮)合成和分泌的机制研究

  4. 国家自然科学基金项目(30970530):微囊藻毒素低剂量长时间暴露对雄性大鼠生殖系统的影响及其机制研究

  5. 国家自然科学基金项目(81170054):调控Wnt信号通路对特发性肺纤维化发生发展影响的研究

  6. 国家自然科学基金项目(20577019):环境内分泌干扰物烷基酚生殖毒性风险评价标准的探索

  7. 高等学校博士学科点专项科研基金20130091110050):微囊藻毒素通过下丘脑-垂体-睾丸轴下调雄性激素合成及分泌的机制研究

  8. 江苏省自然科学基金(BE2021707):特发性肺纤维化预警标志物鉴定及靶向干预肺巨噬细胞OPN治疗肺纤维化关键技术研究

  9. 江苏省自然科学基金(BK2011570):调控WNT信号通路对特发性纤维化发生发展影响的研究

  10. 江苏省自然科学基金(BK20151398):Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究

  11. 国家重点基础研究发展计划973”计划课题子项目2010CB945103):卵巢早衰的分子机制及其早期预测、诊断生物标记的研究

  12. 国家重点基础研究发展计划973”计划课题子项目(2007CB815603):微生物群落分解矿物的机理及其对生态环境的影响

获奖情况

2021年获必赢76net线路“赵世良讲座教授”称号。

2018年获必赢76net线路本科实践教学优秀指导教师称号。

2017年获宝钢优秀教师奖称号。

2010年获必赢76net线路我最喜爱的教师称号。

发表论文

  1. Pan Chun, Yan Minghao, Jin Haibo, Guo Hongqian*, 韩晓冬* Chronic exposure to MC-LR increases the risks of microcytic anemia: Evidence from human and mice. Environ Pollut. 2021 Nov 1; 288:117966. doi: 10.1016/j.envpol.2021.117966.

  2. Minghao Yan, Shen Gu, Chun Pan, Yabing Chen,韩晓冬* MC-LR-induced interaction between M2 macrophage and biliary epithelial cell promotes biliary epithelial cell proliferation and migration through regulating STAT3. Cell Biol Toxicol Published:21 January 2021 https://doi.org/10.1007/s10565-020-09575-9  

  3. Ma Yuhan, Wang Jing, Xu Dihui, Chen Yabing*, 韩晓冬*. Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway. Science of The Total Environment, Available online 29 June 2021, 148732.

  4. Ji Jie, Hou Jiwei, Xia Yunhui, Xiang Zou, 韩晓冬*. NLRP3 inflammasome activation in alveolar epithelial cells promotes myofibroblast differentiation of lung-resident mesenchymal stem cells during pulmonary fibrogenesis. Biochim Biophys Acta Mol Basis Dis. 20211867:166077.

  5. Chen Yabing, Pan Chun, Wang Xiaotong, Xu Dihui, Ma Yuhan, Hu Jianhang, Chen Peilin, Xiang Zou, Rao Qiu*, 韩晓冬*. Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells. Theranostics 2021; 11(16): 7640-7657.

  6. Xu Dihui, Ma Yuhan, 韩晓冬*, Chen Yabing*. Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells. Journal of Hazard Materials. 2021, 417: 126092.

  7. Hou Jiwei, Ji Qijian, Ji Jie, Ju Shenghong, Xu Chun, Yong Xueqing, Xu Xiaoxuan, Muddassir Mohd, Chen Xiang, Xie Jinbing*, 韩晓冬*.Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast -targeting polymeric micelles for idiopathic pulmonary fibrosis therapy. Theranostics. 2021 Jan 9; 11(7):3244-3261. Theranostics. 202111: 3244-3261.

  8. Jin Haibo, Ma Tan, Sha Xiaoxuan, Liu Zhengyu, Zhou Yuan, Meng Xiannan, Chen Yabing, 韩晓冬*, Die Jie*. Polystyrene microplastics induced male reproductive toxicity in mice. Journal of Hazardous Materials, 2021401: 123430.

  9. Chen Yabing, Wang Jing, Xu Dihui, Xiang Zou, Ding Jie, Yang Xiaoyu, Li Dongmei*, 韩晓冬*. m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. Autophagy. 2021,17(2):457-475.

  10. Xu Dihui, Wang Jing, Ma Yuhan, Ding Jie, 韩晓冬, Chen Yabing. Microcystin-leucine-arginine induces apical ectoplasmic specialization disassembly. Chemosphere. 2021264:128440.

  11. Pan Chun, Zhang Ling, Meng Xiannan, Qin Haixiang, Xiang Zou, Gong Wenyue, Luo Wenxin, Li Dongmei, 韩晓冬*. Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells. Chemosphere. 2021263: 128295.

  12. Meng Xiannan, Zhang Ling, Hou Jiwei, Ma Tan, Pan Chun, Zhou Yuan, Han Ruitong, Ding Yuanzhen, Peng Haoran, Zou Xiang, Li Dongmei*, 韩晓冬*. The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)- paternal-exposed offspring mice. Science of the Total Environment. 2020, 736: 139678.

  13. Zhang Changliang, Wang Jing, Zhu Jinling, Chen Yabing, 韩晓冬*. Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. Science of The Total Environment. 2020,703:134702.

  14. Wang Jing, Zhang Changliang, Zhu Jinling, Ding Jie, Chen Yabing , 韩晓冬*. Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR. Science of the Total Environment, 2019, 689: 662–678.

  15. Wang Jing, Chen Yabing, Zhang Changliang, Xiang Zou, Ding Jie*, 韩晓冬*. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of Hazardous Materials, 2019, 373: 504–518.

  16. Meng Xiannan, Peng Haoran, Ding Yuanzhen, Zhang Ling, Yang Jingping, 韩晓冬*. A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity. Science of the Total Environment, 2019, 667: 563–577.

  17. Hou Jiwei, Shi Jingyan, Chen Ling, Lv Zhongyang, Chen Xiang, Cao Honghui, Xiang Zou, and 韩晓冬*. M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Communication and Signaling. 2018 ,16:89, doi: 10.1186/s12964-018-0300-8.

  18. Pan Chun, Chen Yabing, Xu Tianchi, Wang Jing, Li Dongmei, and 韩晓冬*. Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia. Environmental Pollution. 2018,242: 1535-1545.

  19. Ding Jie, Wang Jing, Jin Haibo, Xia Tianjiao, Chen Yi, Wu Jiang, and 韩晓冬*. Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice. Science of the Total Environment. 2018, 643:496–506.

  20. Chen Xiang, Shi Chaowen, Cao Honghui, Chen Ling, Hou Jiwei, Xiang Zou, Hu Kebin, and 韩晓冬*. The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis. Cell Death & Disease. 2018,9:639.

  21. Chen Yabing, Wang Jing, 韩晓冬*, et al. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, 2018, 75(6):1117-1132.

  22. Chaowen Shi, Xiang Chen, Zhaorui Sun, Zou xiang, Weiping Qian,韩晓冬*. Intracellular SERS probes based on -conjugated AuNSs for distinguishing between the differentiation of lung resident mesenchymal stem cells. Biomaterials. 2015, 58:10-25.

  23. Yuan Zhou, Zou Xiang, Dongmei Li*, 韩晓冬*. Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96. Environmental Science and Technology. 2014,48:6383-6390.