高 千

姓名

高 千

研究方向

疾病分子机制

联系方式

电话：18795890567

Email：qian_gao@nju.edu.cn

学术兼职：

自然科学基金委重点项目及杰出青年基金评委

江苏省分子医学重点实验室 主任

个人简介

教授，博士生导师，美国宾夕法尼亚大学必赢76net线路神经生物学博士，浙江杭州人。

国内完整临床医学训练，先后在美国麻省理工学院和耶鲁大学必赢76net线路做博士后研究。

2004年受聘为耶鲁大学必赢76net线路助理教授，2007年受聘为必赢76net线路教授。

主要领域为疾病的分子机制及代谢机制研究。

代表性论文[近5年通讯作者和第一作者]

1、Song S, Min H, Niu M, Wang L, Wu Y, Zhang B, Chen X, Liang Q, Wen Y, Wang Y, Yi L, Wang H, Gao Q. S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation. EBioMedicine. 2018 Nov;37:168-176.

2、He X, Chen X, Wang L, Wang W, Liang Q, Yi L, Wang Y, Gao Q. Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux. Life Sci. 2019 Jan 1;216:67-74. doi: 10.1016/j.lfs.2018.09.024.

3、Zhang B, Zhao F, Mao H, Ma W, Zhang Y, Zhang X, Ding J, Gao Q, Wen Y.Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis. Int Immunopharmacol. 2018 Nov;64:208-216.

4、Chen X, Yi L, Song S, Wang L, Liang Q, Wang Y, Wu Y, Gao Q. Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes. Life Sci. 2018 Aug 1;206:84-92.

5、Wen Y, Ding J, Zhang B, Gao Q. Bone marrow-derived mononuclear cell therapy for nonischaemic dilated cardiomyopathy-A meta-analysis.Eur J Clin Invest. 2018 Apr;48(4).

6、Chen X, Wang L, Fan S, Song S, Min H, Wu Y, He X, Liang Q, Wang Y, Yi L, Gao Q. Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor. Eur J Pharmacol. 2018 Jan 5;818:115-123.

7、Chen X, Wang L, Wu Y, Song S, Min H, Yan Y, He X, Liang Q, Yi L, Wang Y, Gao Q. Effect of Puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscle in diabetic rats.Nutrition＆Diabetes. Diabetes. 2018 Jan 12;8(1):1.

8、Deng Z, Jin J, Wang Z, Wang Y, Gao Q, Zhao J.The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening. Int J Nanomedicine. 2017; 12: 3617–3636.

9、Song S, Su Z, Xu H, Niu M, Chen X, Min H, Zhang B, Sun G, Xie S, Wang H, Gao Q. Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1. Cell Death Dis. 2017 Feb; 8(2): e2612..

10、Min H, Fan S, Song S, Zhuang Y, Li H, Wu Y, Cai H, Yi L, Dai J, Gao Q. Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis. Diagn Pathol. 2016;23;11:135.

11、Deng Z, Wang Z, Jin J, Wang Y, Bao N, Gao Q, Zhao J. SIRT1 Protects Osteoblasts against Particle-induced Inflammatory Responses and Apoptosis in Aseptic Prosthesis Loosening. Acta Biomater. 2016 Nov 23.

12、Zhang X, Ma D, Zou W, Ding Y, Zhu C, Min H, Zhang B, Wang W, Chen B, Ye M, Cai M, Pan Y, Cao L, Wan Y, Jin Y, Gao Q, Yi L. A rapid NGS strategy forcomprehensive molecular diagnosis of Birt-Hogg-Dub syndrome in patients with primary spontaneous pneumothorax. Respir Res. 2016 May 27;17(1):64.

13、Xia Y, Wang W, Wang L, Shen S, Cao Y, Yi L, Gao Q, Wang Y. hOGG1 gene polymorphisms and susceptibility to polycystic ovary syndrome. Biomed Rep. 2016 Apr;4(4):421-426.

14、Zhang B, Xie S, Su Z, Song S, Xu H, Chen G, Cao W, Yin S, Gao Q, Wang H. Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling. Sci Rep. 2016 Feb 19;6:21132.

15、Yang Y, Chen X, Min H, Song S, Zhang J, Fan S, Yi L, Wang H, Gu X, Ma Z, Gao Q. Persistent mitoK(ATP) Activation Is Involved in the Isoflurane-induced Cytotoxicity. Mol Neurobiol. 2016 Jan 23.

16、Yang Y, Song S, Min H, Chen X, Gao Q. STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. Neuroreport. 2016 Jan20;27(2):124-30.

17、Huang X, Jin J, Shen S, Xia Y, Xu P, Zou X, Wang H, Yi L, Wang Y, Gao Q.Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line. Gynecol Endocrinol. 2016;32(3):201-5.

18、Min H, Ding J, Wen Y, Ma X, Gao Q. Combinatorial Treatment of Bone Marrow Transplantation and Regulatory T Cells Improves Glycemia in Streptozotocin-diabetic Mice. Exp Clin Endocrinol Diabetes. 2015;123:638-44.

19、Ding Y, Zou W, Zhu C, Min H, Ma D, Chen B, Ye M, Pan Y, Cao L, Wan Y, Zhu Q, Xia H, Zhang W, Feng Y, Gao Q, Yi L. Promoter methylation is not associated with FLCN irregulation in lung cyst lesions of primary spontaneous pneumothorax. Mol Med Rep. 2015 Nov;12(5):7770-6.

20、Zhang X, Wang T, Wang W, Ding Y, Zhou L, Chen Q, Gao X, Wu Y, Mei Y, Jin Y, Gao Q, Yi L. Does familial breast cancer and thymoma suggest a cancer syndrome? A family perspective. Gene. 2015 Dec 1;573(2):333-7.

21、Chen J, Shen S, Tan Y, Xia D, Xia Y, Cao Y, Wang W, Wu X, Wang H, Yi L, Gao Q, Wang Y. The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. J Ovarian Res. 2015 Mar 22;8:11.

22、Ding Y, Zhu C, Zou W, Ma D, Min H, Chen B, Ye M, Pan Y, Cao L, Wan Y, Zhang W, Meng L, Mei Y, Yang C, Chen S, Gao Q, Yi L. FLCN intragenic deletions in Chinese familial primary spontaneous pneumothorax. Am J Med Genet A. 2015May;167A(5):1125-33.

23、Xie S, Su Z, Zhang B, Ge J, Song S, Sun G, Sun X, Yi L, Wang Y, Sun W, Wang H, Gao Q. SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice. J Invest Dermatol. 2015 Jul;135(7):1915-8.

24、Ding Y, Yang M, She S, Min H, Xv X, Ran X, Wu Y, Wang W, Wang L, Yi L, Yang Y, Gao Q. iTRAQ-based quantitative proteomic analysis of cervical cancer. Int J Oncol. 2015 Apr;46(4):1748-58.

25、Dai J, Cai H, Zhuang Y, Wu Y, Min H, Li J, Shi Y, Gao Q, Yi L. Telomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a Chinese population. Respirology. 2015 Jan;20(1):122-8.

26、Zhang W, Shen L, Deng Z, Ding Y, Mo X, Xu Z, Gao Q, Yi L. Novel missense variants of ZFPM2/FOG2 identified in conotruncal heart defect patients do not impair interaction with GATA4. PLoS One. 2014 Jul 15;9(7):e102379.

27、Wen Y, Xu J, Ma X, Gao Q. High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials. Am J Cardiovasc Drugs. 2013 Dec;13(6):435-42.

28、Ma X, Ding J, Min H, Wen Y, Gao Q. Protective role of low-dose TGF-b 1 in early diabetic nephropathy induced by streptozotocin. Int Immunopharmacol. 2013 Nov;17(3):752-8.

29、Zhang X, Zhang C, Shen S, Xia Yj, Yi L, Gao Q, Wang Y. Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum Reprod. 2013 Nov;28(11):3074-85.

30、Xu P, Shen SM, Zhang XL, Liang F, Xie GB, Yi L, Gao Q, Wang Y. Haplotype analysis of single nucleotide polymorphisms in anti-M llerian hormone gene in Chinese PCOS women. Arch Gynecol Obstet. 2013 Jul;288(1):125-30.

31、Zhang X, Su Z, Zhang X, Hu C, Yu J, Gao Q, Wang H. Generation of Mycobacterium tuberculosis-specific recombinant antigens and evaluation of the clinical value of antibody detection for serological diagnosis of pulmonary tuberculosis. Int J Mol Med. 2013 Mar;31(3):751-7.

32、Xie GB, Xu P, Che YN, Xia YJ, Cao YX, Wang WJ, Qiao D, Wu XK, Yi L, Gao Q, Wang Y. Microsatellite polymorphism in the fibrillin 3 gene and susceptibility to PCOS: a case-control study and meta-analysis. Reprod Biomed Online. 2013 Feb;26(2):168-74.

承担科研项目[项目负责人]

银屑病代谢综合征共同免疫机制研究，国家自然科学基金（81570775），2016-2019，68万元，课题负责人；

获奖情况

N/A