基本信息

朱昱敏，女，2015年6月于必赢76net线路获学士学位，2020年6月于清华大学获博士学位。

研究方向

多组学与生物信息学，关注母婴健康、血管疾病等领域。

1.疾病生物标志物鉴定及风险预测模型开发

结合队列研究、生物信息学算法、分子生物学实验和人工智能模型，鉴定可用于疾病早期诊断或预后监测的生物标志物，并构建精准预测智能模型。

2.医学大数据整合研究及基因调控网络构建

整合多组学等生物医学大数据，从表观遗传、转录调控、转录后调控、翻译调控等多层面描绘疾病发生发展过程中的基因调控图谱，揭示靶标基因。

成果简介

主持国家级、省部级、校级科研项目6项，作为项目骨干参与国家级科研项目多项；在Cell Research、Nucleic Acids Research等国内外重要学术期刊上发表学术论文20余篇；申请国家发明专利3项，已授权1项。指导本科生获得国家级老员工创新训练项目1项、省级老员工创新训练项目1项，必赢76net线路安邦书院“金种子”早期科研训练项目1项，并在多项教学竞赛中获得优异成绩。

1. Ren, J., Wang, Y., Zhang, Y., Jin, H., Cheng, J., Tao, F., & Zhu, Y. (2024). Placental Transcriptomic Signatures of Prenatal Phthalate Exposure and Identification of Placenta-Brain Genes Associated with the Effects of Phthalate Exposure on Neurodevelopment in Children. Environmental science & technology,58(43), 19141–19151.

2. Jin, H., Wang, X., Li, L., Rui, C., Gan, H., Wang, Q., Tao, F., & Zhu, Y. (2024). Integrated proteomic and transcriptomic landscape of human placenta in small for gestational age infants. iScience, 27, 111423.

3. Zhu, Y., Zhang, Y., Jin, Y., Jin, H., Huang, K., Tong, J., Gan, H., Rui, C., Lv, J., Wang, X., Wang, Q., & Tao, F. (2023). Identification and prediction model of placenta-brain axis genes associated with neurodevelopmental delay in moderate and late preterm children. BMC medicine, 21(1), 326.

4. Jin, H., Zhang, Y., Fan, Z., Wang, X., Rui, C., Xing, S., Dong, H., Wang, Q., Tao, F., & Zhu, Y. (2023). Identification of novel cell-free RNAs in maternal plasma as preterm biomarkers in combination with placental RNA profiles. Journal of translational medicine, 21(1), 256.

5. Xing, S., Zhu, Y., You, Y., Wang, S., Wang, H., Ning, M., Jin, H., Liu, Z., Zhang, X., Yu, C., & Lu, Z. J. (2023). Cell-free RNA for the liquid biopsy of gastrointestinal cancer. Wiley interdisciplinary reviews. RNA, 14(5), e1791.

6. Ren, J., Jin, H., & Zhu, Y. (2023). The Role of Placental Non-Coding RNAs in Adverse Pregnancy Outcomes. International journal of molecular sciences, 24(5), 5030.

7. Yao, Y., Liu, K., Wu, Y., Zhou, J., Jin, H., Zhang, Y., & Zhu, Y. (2022). Comprehensive landscape of the functions and prognostic value of RNA binding proteins in uterine corpus endometrial carcinoma. Frontiers in molecular biosciences, 9, 962412.

8. Zhu, Y., Wang, S., Xi, X., Zhang, M., Liu, X., Tang, W., Cai, P., Xing, S., Bao, P., Jin, Y., Zhao, W., Chen, Y., Zhao, H., Jia, X., Lu, S., Lu, Y., Chen, L., Yin, J., & Lu, Z. J. (2021). Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer. Theranostics, 11(1), 181-193.

9. Zhu, Y., Xu, G., Yang, Y. T., Xu, Z., Chen, X., Shi, B., Xie, D., Lu, Z. J., & Wang, P. (2019). POSTAR2: deciphering the post-transcriptional regulatory logics. Nucleic acids research, 47(D1), D203-D211.

10. Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., Jing, D., Ji, K., & Shi, Y. (2023). LilrB3 is a putative cell surface receptor of APOE4. Cell research, 33(2), 116-130.

11. Tao, Y., Xing, S., Zuo, S., Bao, P., Jin, Y., Li, Y., Li, M., Wu, Y., Chen, S., Wang, X., Zhu, Y., Feng, Y., Zhang, X., Wang, X., Xi, Q., Lu, Q., Wang, P., & Lu, Z. J. (2023). Cell-free multi-omics analysis reveals potential biomarkers in gastrointestinal cancer patients' blood. Cell reports. Medicine, 4(11), 101281.

12. Wang, Z., Zheng, Z., Zhu, Y., Kong, S., & Liu, D. (2023). PHOSPHATE RESPONSE 1 family members act distinctly to regulate transcriptional responses to phosphate starvation. Plant physiology, 191(2), 1324–1343.

13. Huang, B., Zhao, W., Cai, X., Zhu, Y., Lu, Y., Zhao, J., Xiang, N., Wang, X., Deng, H., Tang, X., Liu, L., Zhao, Y., & Shi, Y. (2023). Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells. International journal of molecular sciences, 24(13), 11131.

14. Zhao, W., Zhang, S., Zhu, Y., Xi, X., Bao, P., Ma, Z., Kapral, T. H., Chen, S., Zagrovic, B., Yang, Y. T., & Lu, Z. J. (2022). POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins. Nucleic acids research, 50(D1), D287–D294.

15. Tong, J., Liang, C., Wu, X., Huang, K., Zhu, B., Gao, H., Zhu, Y., Li, Z., Qi, J., Han, Y., Ding, P., Zhu, Y., & Tao, F. (2022). Prenatal serum thallium exposure and cognitive development among preschool-aged children: A prospective cohort study in China. Environmental pollution (Barking, Essex : 1987), 293, 118545.

16. Tan, C., Cao, J., Chen, L., Xi, X., Wang, S., Zhu, Y., Yang, L., Ma, L., Wang, D., Yin, J., Zhang, T., & John Lu, Z. (2019). Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma. Clinical chemistry, 65(7), 905–915.

17. Yuan, J., Li, J., Yang, Y., Tan, C., Zhu, Y., Hu, L., Qi, Y., & Lu, Z. J. (2018). Stress-responsive regulation of long non-coding RNA polyadenylation in Oryza sativa. The Plant journal : for cell and molecular biology, 93(5), 814–827.

18. Hu, B., Yang, Y. T., Huang, Y., Zhu, Y., & Lu, Z. J. (2017). POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins. Nucleic acids research, 45(D1), D104–D114.

19. Xi, X., Li, T., Huang, Y., Sun, J., Zhu, Y., Yang, Y., & Lu, Z. J. (2017). RNA Biomarkers: Frontier of Precision Medicine for Cancer. Non-coding RNA, 3(1), 9.

20. 朱昱敏，刘吉梓，周游，王方旭，潘鸣飞，张方舟，曹晨，沈艳，顾宁. 细胞生物信息学应用于疾病诊断的前景. 2023，v.40 (04) 533-542.

主持

中央高校基本科研业务费——AI&AI for Science青年项目

国家自然科学基金青年项目

安徽省自然科学基金青年项目

安徽省转化医学研究院重点项目

参与

国家自然科学基金区域创新联合基金

国家自然科学基金面上项目

2015，必赢76net线路优秀毕业生

2018，博士研究生国家奖学金

2021，课程创新创业教学竞赛校赛二等奖

2022，第二届全国高校教师教学创新大赛校赛二等奖