助理教授、博导，江苏省“优秀青年”基金获得者。曾获得中国细胞生物学会未来女科学计划提名、中国免疫学会第十一届青年学者奖提名。

研究方向：1）2型糖尿病和肥胖演进的时空网络调控，2）脂肪组织的免疫代谢调节，3）基于工程化真菌的产热脂肪活化。致力于针对糖尿病分期分型及并发症的新型AI诊疗体系研发与机制探讨，并建立了“临床表征AI图像识别—粪便代谢物—肠道共生菌—免疫微环境”的全链条研究体系。

研究成果：发表SCI论文20余篇，以第一作者或通讯作者在Nat Commun.、Clin and Tran Med、Int J Biol Sci、J Pathol.、J Biol Chem.等期刊等国际高水平学术期刊发表论文10余篇；申请国内外发明专利4项，授权2项，PCT国际专利授权1项。主持国家自然科学基金专项项目、面上项目、青年基金项目、中国博士后基金各1项，主持江苏省自然科学优秀青年基金和青年基金各1项，作为课题骨干参与国家重点研发计划重点专项1项，重大研究计划1项，负责省市级课题多项。

教学工作：主持面向本科生、研究生等多个专业课程；参与校级各类教学改革项目；曾获必赢76net线路教师教学竞赛优秀奖等多个奖项；指导本科生荣获全国老员工基础医学创新论坛全国赛区金奖（1次）、银奖（1次），华东赛区一等奖（2次）。

中国生物物理学会代谢生物学分会青年理事

江苏省免疫学会青年工作委员会常委兼秘书长

江苏省免疫学会免疫与代谢专委会常委

江苏省医学会整合医学研究会常委

Frontiers in Endocrinology、Medcomm等期刊审稿专家

1、Yue Zhao, Meng-Fei Zhao, Shan Jiang, Jing Wu, Jia Liu, Xian-Wen Yuan, Di Shen, Jing-Zi Zhang, Nan Zhou, Jian He, Lei Fang*, Xi-Tai Sun*, Bin Xue*, Chao-Jun Li*. Liver Governs Adipose Remodelling via Extracellular Vesicles in Response to Lipid Overload. Nat Commun. 2020;11(1):719. (IF=16.6)

2、Baochao Li, Yuqin Jin, Bingqing Zhang, Tong Lu, Jialing Li, Jingzi Zhang, Yiwen Zhou, Yanyi Wang, Caixia Zhang, Yue Zhao*, Huang Li*. Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity. Clin. Transl. Med. 2024;14:e70029.

3、Yue Zhao, Tian-Yu Wu, Meng-Fei Zhao, and Chao-Jun Li*. The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease. J Biol Chem. 2020 Apr 10;295(15):5152-5162.

4、Yue Zhao#,*, Meng-Fei Zhao#, Mei-Lin Yang#, Tian-Yu Wu, Cong-Jian Xu, Jing-Mei Wang, Chao-Jun Li*, Xi Li*. G-Protein-Coupled Receptor 30 Mediates the Anticancer Effects Induced by Eicosapentaenoic Acid in Ovarian Cancer Cells. Cancer Res Treat. 2020 Jul;52(3):815-829.

5、Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y*, Zhao S*, Wang T*. Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis. International Journal of Biological Sciences. 2023; 19(14): 4672-4688.

6、Danyang Chong#, Zhong Chen#, Shan Guan, Tongyu Zhang, Na Xu, Yue Zhao*, Chaojun Li*. Geranylgeranyl pyrophosphate regulates endothelial cell proliferation and anti- apoptosis during vascular development in the mouse embryo through mediating protein geranylgeranylation. J Genet Genomics. 48(2021):300-311.

7、Yue Zhao, Ya-Dong Zhang, You-You Zhang, Shu-Wen Qian, Zhi-Chun Zhang, Shu-Fen Li, Liang Guo, Yuan Liu, Bo Wen, Qun-Ying Lei, Qi-Qun Tang, Xi Li. p300-Dependent Acetylation of ATF5 Enhances C/EBPβ Transactivation of C/EBPα During 3T3-L1Differentiation. Mol Cell Biol. 2014,34(3):315-324.

8、Jia Liu#, Shan Jiang#, Yue Zhao#, Qian Sun, Jing-Zi Zhang, Di Shen, Jing Wu, Ning Shen, Xiao Fu, Xi-Tai Sun, De-Cai Yu, Jun Chen, Jian He, Ting-Ting Shi, Yi-Tao Ding, Lei Fang, Bin Xue*, Chao-Jun Li*. Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. J Pathol. 2018;246(3):277-288. (Commentary by Fullerton MD. Does prenylation predict progression in NAFLD? J Pathol. 2019)

9、Jing-Hui Jiang#, Yue Zhao#, Liu-Ling Xiao, Cui-Song Zhu, Shu-Fen Li, Xi Li. Activating transcription factor 5 regulates lipid metabolism in adipocytes. Science Bulletin. 2016;61(23):1802–1809.

10、Qiao-Li Tang, Shan Jiang, Wen-Jun Jia, Di Shen, Yu-Dong Qiu, Yue Zhao*, Bin Xue*, Chao-Jun Li*. Zoledronic acid, an FPPS inhibitor, ameliorates liver steatosis through inhibiting hepatic de novo lipogenesis. Eur J Pharmacol. 2017;814:169-177.

11、Dan-Dan Zhao, Jing Wu, Yin-Juan Zhao, Wei Shao, Qi Cheng, Xiao-Yan Shao, Xian-Wen Yuan, Juan Ye, Jian-Pu Gao, Mei-Ling Jin, Chao-Jun Li, Xiao-Lin Chen, Yue Zhao* and Bin Xue*. Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis. Cancer Cell Int (2020) 20:46.

12、Ruoyu Zhao , Binghao Wang, Yan Guo, Jingzi Zhang, Danqi Chen, Wei Ming He, Yong Juan Zhao , Yibing Ding , Chunyuan Jin, Chaojun Li, Yue Zhao*, Wei Ren*, Lei Fang*.Quantitative Proteomics Reveals Arsenic Attenuates Stem-Loop Binding Protein Stability via a Chaperone Complex Containing Heat Shock Proteins and ERp44. Proteomics. 2021 Aug;21(16):e2100035.

13、Jing Wu, Dandan Bu, Haiquan Wang, Di Shen, Tongyu Zhang, Weiwei Tao, Mengfei Zhao, Yue Zhao, Peng Li, Bin Xue* & Chao-Jun Li*. The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice. Nat Commun. 2023(14):1634.

14、Zhi-Chun Zhang, Yan Liu, Liu-Ling Xiao, Shu-Fen Li, Jing-Hui Jiang, Yue Zhao, Shu-Wen Qian, Qi-Qun Tang, Xi Li. Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. J Hepatol. 2015;63(6):1466-75.

15、Jing-Zi Zhang, Ruo-Yu Zhao, Clinton Yu, Christine L. N., Bryant Kenneth Wu, Zhi-Hong Liu, Yi-Bing Ding, Yue Zhao, Bin Xue, Zhen-Qiang Pan, Chao-Jun Li*, Lan Huang*, Lei Fang*. IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. J Proteome Res. 2020;19(3):1119-1130.

16、Jing-Zi Zhang, Neng Tang, Yin-Juan Zhao, Ruo-Yu Zhao, Xiao Fu, Dan-Dan Zhao, Yue Zhao, Lan Huang, Chao-Jun Li, Yu-Dong Qiu*, Bin Xue*, Lei Fang*. Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice. J Proteome Res. 2020;19(4):1788-1799.

17、Jing Wu, Wei-Wei Tao, Dan-Dan Bu, Yue Zhao, Tong-Yu Zhang, Dan-Yang Chong, Bin Xue, Zhen Xing, Chao-Jun Li. Egr-1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia-induced insulin resistance in the liver in type 2 diabetes. FEBS Lett. 2019;593(21):3054-3063.

18、Zhi-Chun Zhang, Yuan Liu, Shu-Fen Li, Liang Guo, Yue Zhao, Shu-Wen Qian, Bo Wen, Qi-Qun Tang and Xi Li. Suv39h1 Mediates AP-2α-Dependent Inhibition of C/EBPα Expression during Adipogenesis. Mol Cell Biol. 2014;34(12):2330-8.

19、Shu-Fen Li, Liang Guo, Shu-Wen Qian, Yuan Liu, You-You Zhang, Zhi-Chun Zhang, Yue Zhao, Jian-You Shou, Qi-Qun Tang, Xi Li. G9a is Transactivated by C/EBPβ to Facilitate Mitotic Clonal Expansion during 3T3-L1 Preadipocyte Differentiation. Am J Physiol Endocrinol Metab. 2013;304(9):E990-8.

20、Yong-Juan Sang#, Qiang Wang#, Feng Zheng, Yue Hua, Xin-Ying Wang, Jing-Zi Zhang, Kang Li, Hai-Quan Wang, Yue Zhao, Min-Sheng Zhu*, Hai-Xiang Sun*, Chao-Jun Li*. Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. J Mol Cell Biol. 2021;13(2):116-127.

21、Dan-Dan Zhao, Jun Yuan, Qi Cheng, Ya-Ling Qi, Ke Lu, Shan-Shan Lai, Qian Sun, Yue Zhao, Lei Fang, Mei-Ling Jin, De-Ccai Yu, Yu-Dong Qiu, Chao-Jun Li, Jun Chen, Bin Xue. Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncol Lett. 2019;17(2):1523-1530. 

1.国家自然科学基金专项项目，T2341015，2024/01-2026/12，主持

2.国家自然科学基金面上项目，32271182，2023/01-2026/12，主持

3.国家自然科学基金青年基金项目，31601153，2017/01-2019/12，主持

4.江苏省科学基金优秀青年基金项目，BK20200061，2020/07-2023/06，主持

5.江苏省科学基金青年基金项目，BK20160619，2016/07-2019/06，主持

6.中国博士后基金面上项目，2016M601778，2016/01-2017/12，主持

7.中央高校基本科研业务费-国际合作交流项目、原创与交叉研究项目、国家自然科学基金培育项目、国家重点平台研究项目等，主持

8.国家重大研究计划“糖脂代谢的时空网络调控”项目，91857109，2019/01-2023/12，参与

9.国家重点研发计划重点专项，2018YFC1004700，2018/12-2021/12，参与

10.江苏省社会发展基金面上项目，BE2017708，2017/07-2020/06，参与

1.江苏省“优秀青年”基金获得者，2020

2.必赢76net线路新华报业优秀青年教师奖，2021

3.必赢76net线路第一届必赢76net线路教师教学竞赛优秀奖，2021

4.必赢76net线路本科生招生先进个人，2023

5.必赢76net线路育教融合奖，2024

6.必赢76net线路研究生招生先进个人，2024