袁阿虎博士
副教授/博士生导师
电话:邮箱:yuannju@nju.edu.cn 地址:南京市汉口路22号研究方向:

微纳米制剂及其在肿瘤免疫治疗中的应用

  • 个人简介
  • 学术兼职
  • 代表性论文
  • 承担科研项目
  • 获奖情况

工作简历:

2024.07~至今        必赢76net线路 博士生导师

2019.12~至今        必赢76net线路 副教授

2015.09~2019.11  必赢76net线路 副研究员


科研情况简介:

副教授,博士生导师,曾在美国北卡罗莱纳大学教堂山分校(University of North Carolina at Chapel Hill)药学院访学。近年来,主要关注微纳米药物自组装机制、规模化制备及其在抗肿瘤免疫治疗中的应用。围绕该领域,在Nature Communications, Advanced MaterialsAdvanced ScienceACS Nano, Advanced Functional Materials(封面论文)等期刊发表SCI论文40余篇。获得2017年教育部技术发明一等奖2018年江苏省专利金奖、2019年江苏省科协青年科技人才托举工程、2020年教育部自然科学一等奖、2022年江苏省333高层次人才(第3层次)等奖项或支持。


中国药学会 会员;中国化学会 会员;Nanomaterials 期刊编委;

Nature Communications, Advanced MaterialsACS NanoJ Controlled Release等期刊审稿人;


[1] Zhusheng Huang, Rong Gu, Shiqian Huang, Qian Chen, Jing Yan, Xiaoya Cui, Haojie Jiang, Dan Yao, Chuang Shen, Jiayue Su, Tao Liu, Jinhui Wu, Zhimin Luo*, Yiqiao Hu*, Ahu Yuan*Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination,Nature Communications, 2024. 

[2] Yuxiang Wang, Weiran Wang, Rong Gu, Jing Chen, Qian Chen, Tingsheng Lin*, Jinhui Wu, Yiqiao Hu*Ahu Yuan*In Situ Vaccination with Mitochondria-Targeting Immunogenic Death Inducer Elicits CD8+ T Cell-Dependent Antitumor Immunity to Boost Tumor ImmunotherapyAdvanced Science, 2023. 

[3] Qian Chen, Jing Chen, Qingqing Zhang, Peizheng Yang, Rong Gu, Hao Ren, Yue Dai, Shiqian Huang, Jinhui Wu, Xudong Wu*, Yiqiao Hu*, Ahu Yuan*, Combining High-Z Sensitized Radiotherapy with CD73 Blockade to Boost Tumor Immunotherapy, ACS Nano, 2023.

[4] Yuxiang Wang, Jing Chen, Rumeng Duan, Rong Gu, Weiran Wang, Jinhui Wu, Huibo Lian*, Yiqiao Hu*, Ahu Yuan*High-Z-Sensitized Radiotherapy Synergizes with the Intervention of the Pentose Phosphate Pathway for In Situ Tumor VaccinationAdvanced Materials, 2022.

[5] Zhusheng Huang, Dan Yao, Jinhui Wu, Yiqiao Hu* and Ahu Yuan*, Gadolinium–Zoledronic acid Coordination Polymer Nanorods for Improved Tumor Radioimmunotherapy by Synergetically Inducing Immungenic Cell Death and Reprogramming Immunosuppressive Microenvironment, ACS nano, 2021.

[6] Zhusheng Huang, Yuxiang Wang, Dan Yao, Jinhui Wu, Yiqiao Hu*, Ahu Yuan*, Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress, Nature Communications, 2021.

[7] Yuxiang Wang, Yawen Ding, Dan Yao, Hong Dong, Changwei Ji*, Jinhui Wu, Yiqiao Hu* and Ahu Yuan*, Copper-Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T-Cell Infiltration, Small, 2021.

[8] Shaoju Gan, Xiaoning Tong , Yue Zhang, Jinhui Wu, Yiqiao Hu*, and Ahu Yuan*Covalent Organic Framework-Supported Molecularly Dispersed Near-Infrared Dyes Boost Immunogenic Phototherapy against TumorsAdvanced Functional Materials, 2019 (Cover Story). 

[9] W. Wang, Y. Cheng, P. Yu, H. Wang, Y. Zhang, H. Xu, Q. Ye, A. Yuan*, Y. Hu*, J. Wu*, Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy, Nature Communications, 2019.

[10] Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu*, Yiqiao Hu*Ahu Yuan*, Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal EffectsACS nano, 2018.

https://scholar.google.com/citations?hl=en&user=7ccGPxsAAAAJ


[1] 2024-2027年,长三角科技创新共同体联合攻关项目(参与,研究骨干);

[2] 2024-2027,国家自然科学基金面上项目(项目负责人);

[3] 2022-2025,江苏省自然科学基金面上项目(项目负责人);

[4] 2022-2027年,国家重点研发计划“前沿生物技术”重点专项(参与,研究骨干);

[5] 2018-2020年,中央高校基本科研业务经费(项目负责人);

[6] 2017-2022年,国家重点研发计划“纳米科技”重点专项(参与,研究骨干);

[7] 2016-2019,国家自然科学青年基金项目(项目负责人);

[1] 2017年,教育部技术发明一等奖(第3完成人);

[2] 2018年,南京市高层次人才(高校C类人才);

[3] 2018年,江苏省专利金奖(主要专利发明人);

[4] 2019年,江苏省科协青年科技人才托举工程

[5] 2020年,教育部自然科学一等奖(第4完成人);

[6] 2022年,江苏省第六期333人才(第三层次);