必赢76net线路(China)-BD官方认证

教育经历：

2000.9-2009.8 必赢76net线路必赢76net线路本硕博连读肿瘤学

2008.8-2009.6 美国University of Pittsburgh 联合培养博士研究生

工作经历：

2009.9-2011.12 必赢76net线路讲师

2012.1-2017.12 必赢76net线路副教授、硕士生导师

2014.3-2016.3 美国MD Anderson Cancer Center 博士后

2018.1-至今必赢76net线路教授、博士生导师

世中联整合肿瘤专委会副会长

中国抗癌协会胃肠病学专委会常务委员

江苏省免疫学会常务理事兼副秘书长

Publications（First or corresponding author）

1. Yang G, Zhang H, Xu Y, Zhao A, Shu P, Wang W, Zhang H*, Wang T*, Yang Y*. Basic Characteristics, Status, and Challenges of Integrative Oncology in China. Integrative Cancer Therapies. 2021. 20:15347354211063504.

2. Lu X, Qiao S, Peng C , Xu Z, Qu J, Hou Y, Zhao S*, Chen P*, Wang T*. Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis. Frontiers in Nutrition. 2021 Nov 12;8:706382.

3. Li D, Lu L, Kong W, Xia X, Pan Y , Li Jing , Wang Jia, Wang T*, Liang J*, Dou H*，Hou Y*. C-type lectin receptor Dectin3 defificiency balances the accumulation and function of FoxO1-mediated LOX-1+ M-MDSCs in relieving lupus-like symptoms. Cell Death and Disease. 2021. 12:829.

4. Qu J, Sun Z, Peng C, Li D, Yan W, Xu Z, Hou Y, Shen S, Chen P, Wang T*. C. tropicalis promotes chemotherapy resistance in colon cancer through increasing lactate production to regulate the mismatch repair system. International Journal of Biological Sciences. 2021. 17(11): 2756-2769.

5. Zhu Y#, Shi T#, Lu X, Xu Z, Qu J, Zhang Z, Shi G, Shen S, Hou Y, Chen Y, Wang T*. Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22. EMBO J. 2021. e105320.

6. Wang Y, Zhang D, Hou Y, Shen S, Wang T*.The adaptor protein CARD9, from fungal immunity to tumorigenesis.Am J Cancer Res. 2020 Aug 1;10(8):2203-2225.

7. Zhang D, Wang Y, Shen S, Hou H, Chen Y, Wang T*. The mycobiota of the human body: a spark can start a prairie fire. Gut Microbes. 2020. Jul 3;11(4):655-679.

8. Li T，Liu L，Hou Y，Shen S，Wang T*.C-type lextin receptor-mediated immune recognition and response of the microbiota in the gut. Gastroentoerology Report. 2019, Apr (8)1-10.

9. Qu J, Liu L, Xu Q, Ren J, Xu Z, Dou H, Shen S, Hou Y*, Mou Y*, Wang T*. CARD9 prevents lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production. Int J Cancer. 2019 Oct 15;145 (8):2225-2237.

10. Wang T*, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hou Y, Hung M, Lin X*. The adaptor protein CARD9 protects against colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells. Immunity 2018,49,1-11.

11. Ren J, Ding L, Zhang D, Shi G，Xu Q, Shen S, Wang Y,Wang T*, Hou Y*.Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018 Jun 24;8(14):3932-3948.

12. Xu H^#，Wang T (co-first author)^#, Yang C^#, Li X, Liu G, Yang Z, Singh P, Krishnan S*, Ding D*. Supramolecular nanofibers of curcumin for highly amplified radiosensitization of colorectal cancers to ionizing radiation. Advanced Functional Material. 2018. Jan, 110-112.

13. Shi G, Li D, Ren J, Li X, Wang T*, Dou H*, Hou Y*. mTOR inhibitor INK128 attenuates dextran sodium sulfate-induced colitis by promotion of MDSCs on Treg cell expansion.J Cell Physiol. 2018 Aug 21.

14. Shi T, Ma Y, Yu L, Jiang J, Shen S, Hou Y, Wang T*. Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints. Int J Mol Sci. 2018 May 7;19(5).

15. Ren J, Hou Y, Wang T*. Roles of estrogens on myeloid-derived suppressor cells in cancer and autoimmune diseases. Cellular & Molecular Immunology 2017,14:1-3.

16. Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, Hou Y*, Wang T*. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017 Sep 18;7(1):11776.

17. Xu Z, Ji J, Xu J, Li D, Shi G, Liu F, Ding L, Ren J, Dou H, Wang T*, Hou Y*. MiR-30a increases MDSC differentiation and immunosuppressive function by targeting SOCS3 in mice with B-cell lymphoma. FEBS J. 2017 Jun 12.

18. Ren J, Ding L, Xu Q, Shi G, Li X , Li X, Ji J, Zhang D, Wang Y, Wang T*, Hou Y*. LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway. Scientific Report. 2017 Apr 7;7(1):749.

19. Wang T, Xu X, Xu Q, Ren J, Shen S*, Fan C*, Hou Y*. miR-19a promotes colitis-associated colorectal cancer by regulating tumor necrosis factor alpha-induced protein 3 (TNFAIP3)-NF-κB feedback loops. Oncogene. 2016. Dec.1-12.

20. Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, Lin X*. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016 Jun 9;12(6):e1005662.

21. Tang R, Xu Y, Ma F, Ren J, Shen S, Du Y, Hou Y*, Wang T*. Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: Potential role for ROS-mediated inhibition on AKT. Bioelectromagnetics. 2016 Feb;37(2):89-98.

22. Tang R, Shen S, Zhao X, Nie Y, Xu Y, Ren J, Lv M, Hou Y*, Wang T*. Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. Stem Cell Res Ther. 2015 Apr 13;6:71.

23. Ren J, Nie Y, Lv M, Shen S, Tang R, Xu Y, Hou Y, Zhao S*, Wang T*. Estrogen up-regulates MICA/B expression in human non-small cell lung cancer through regulation of ADAM17. Cellular & Molecular Immunology. 2015 Nov;12(6):768-76.

24. Lv M, Xu Y, Tang R, Ren J, Shen S, Chen Y, Liu B, Hou Y*, Wang T*. miR141-CXCL1-CXCR2 signaling-induced Treg recruitment regulates metastases and survival of non-small cell lung cancer. Mol Cancer Ther. 2014 Dec;13(12):3152-62.

25. Tang X, Tang R, Xu Y, Wang Q, Hou Y, Shen S*, Wang T*. MicroRNA networks in regulatory T cells. J Physiol Biochem. 2014 70(3) :869–875.

26. Zhu Y, Li J, Bai Y, Wang X, Duan N, Jiang H, Wang T*, Wang W*. Hydroxychloroquine decreases the upregulated frequencies of Tregs in patients with oral lichen planus. Clin Oral Investig. 2014 Nov;18(8):1903-11.

27. Nie Y, Du L, Mou Y, Xu Z, Weng L, Du Y, Zhu Y, Hou Y*, Wang T*. Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune m odulation. BMC Cancer. 2013 Dec 6;13:582.

28. Nie Y, Chen Y, Mou Y, Weng L, Xu Z, Du Y, Wang W, Hou Y*, Wang T*. Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma. PLoS One. 2013 Nov 20;8(11):e72411.

29. Lv M, Mou Y, Wang P, Chen Y, Wang T*, Hou Y*. Diagnostic and predictive role of cell-free midkine in malignant pleural effusions. J Cancer Res Clin Oncol. 2013 Apr;139(4):543-9.

30. Wang T, Lv M, Shen S, Zhou S, Wang P, Chen Y, Liu B, Yu L, Hou Y*. Cell-free microRNA expression profiles in malignant effusion associated with patient survival in non-small cell lung cancer. PLoS One. 2012;7(8):e43268.

31. Zhao G, Nie Y, Lv M, He L, Wang T*, Hou Y*. ERβ-mediated estradiol enhances epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine. Mol Endocrinol. 2012 Aug;26(8):1304-15.

32. Wang T, Lv M, Qian Q, Nie Y, Yu L, Hou Y*. Increased frequencies of T helper type 17 cells in tuberculous pleural effusion. Tuberculosis. 2011 May;91(3):231-7.

33. Wang T, Nie Y, Zhao S, Han Y, Du Y, Hou Y*. Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells. Bioelectromagnetics. 2011 Sep;32(6):443-52.

34. Wang T, Wang L, Qian X, Yu L, Ding Y, Liu B*. Relationship between gene expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in primary cancer cells isolated from malignant ascites. Cancer Invest. 2011 Feb;29(2):130-6.

35. Wang T, Qian X, Wang Z, Wang L, Yu L, Ding Y, Liu B*. Detection of cell-free BIRC5 mRNA in effusions and its potential diagnostic value for differentiating malignant and benign effusions. Int J Cancer. 2009 Oct 15;125(8):1921-5.

36. Liu B, Wang T (co-first author), Qian X, Liu G, Yu L, Ding Y*. Anticancer effect of tetrandrine on primary cancer cells isolated from ascites and pleural fluids. Cancer Lett. 2008 Sep 8;268(1):166-75 .

37. Wang T, Wei J, Qian X, Ding Y, Yu L, Liu B*. Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells .Cancer Lett. 2008 Apr 18;262(2):214-22.

38. Wang T, Qian XP, Liu BR. Survivin: potential role in diagnosis, prognosis and targeted therapy of gastric cancer. World J Gastroenterol. 2007 May 28;13(20):2784-90.

1．国家自然科学基金面上项目，82273011，白色念珠菌外膜囊泡释放毒力因子PMA1调控cDC2细胞代谢重编程促进结肠癌发生发展的机制；2023.1-2026.12，53元，在研，主持

2．国家自然科学基金面上项目，82072648，肠道真菌及其代谢产物通过“肠-肝轴”调控MDSCs代谢和功能促进肝癌发生的作用机制；2021.-2024.12，55元，在研，主持

3．国家自然科学基金面上项目，81772542，CBM信号复合体调控ILC3功能参与结肠肿瘤发生的分子机制；2018.1-2021.12，60万元，在研，主持

4．国家自然科学基金面上项目，81572354，Dectin-3/CARD9通路介导的免疫应答参与炎症相关结肠肿瘤发生发展的机制；2016.1-2019.12，60万元，结题，主持

5．江苏省六大人才高峰高层次人才项目，CBM 信号复合体调控肠道ILC3功能影响肠癌发生的机制；WSW-031；2018.1-2020.12，4万元，在研，主持

6．江苏省自然科学基金面上项目，BK20161400，肠道真菌参与炎症相关结肠肿瘤发生发展的机制；2016.7-2019.6，10万元，在研，主持

7．国家重点研发计划，2017YFA0104300，间充质和神经干细胞的体内动态示踪技术与临床转化研究，2938 万 2017.7-2021.12，在研，参与

8．国家自然科学基金青年项目, 81101552，miR-30d调控K-ras影响肺腺癌微环境中Treg细胞分化的机制研究，2012/01-2014/12，22万元，结题，主持

9．教育部高等学校博士学科点专项科研基金, 20100091120002, 恶性胸腔积液微环境中miR-24对Th17细胞的分化调控机制研究；2011/01-2013/12, 3.6万元，结题，主持

8. 江苏省自然科学基金面上项目，BK2011571，miR-30d调控Treg细胞参与肺腺癌免疫逃逸的机制研究，2012/01-2014/12，8万元，结题，主持

2021年教育部“长江学者奖励计划”青年学者

2021年江苏省杰出青年基金项目

2020年南京十大青年先锋

2020年全球高被引科学家

2018年江苏省“六大人才高峰”高层次人才

2017年仲英青年学者（唐仲英基金会）