主要从事精子发生调控，男性性功能障碍，男性生殖道感染，环境与基因交互作用对人群生殖能力影响的临床及基础研究；注重“中西并重”，在中西医结合诊疗男科疾病上经验丰富；重视临床经验的成果转化，结合临床实践，申请多项发明专利及实用新型专利；注重基础研究向临床应用的转化。作为项目负责人主持国家重点研发计划项目1项，国家自然科学基金3项，省部级课题多项。以第一作者/通讯作者发表论文100余篇，SCI论文30余篇。主编专业著作6部，主编科普著作4部，副主编、参编著作20余部。

[1]Man Yonghong,ShangXuejun,LiuChunyu,ZhangWei,HuangQian,MaSuheng,ShiangRita,ZhangFeng,ZhangLing,ZhangZhibing. Whole-Exome Sequencing Identifies the VHL Mutation (c.262T > C, p.Try88Arg) in Non-Obstructive Azoospermia-Associated Cystic Renal Cell Carcinoma[J]. Current Oncology,2022,29(4).共同第一作者

[2]Li Jiajia,LinShiqi,WuJilei,LiYu,ShangXuejun,PeiLijun. Spatial variation and association between maternal chemical fertilizer exposure and preterm birth in a rural area in Northern China.[J]. Environmental science and pollution research international,2021,29(13).通讯作者

[3]Qu Mengyuan,FengChenzhao,WangXiaotong,GuYiqun,ShangXuejun,ZhouYuanzhong,XiongChengliang,LiHonggang. Association of Serum Testosterone and Luteinizing Hormone With Blood Pressure and Risk of Cardiovascular Disease in Middle-Aged and Elderly Men.[J]. Journal of the American Heart Association,2021,10(7).通讯作者

[4]WeiningLiang,ZhigangWu,GuoweiZhang,WeikangChen,XiangnongHu,JianjunYang,JieMeng,YanZeng,HongjunLi,Xuejun Shang. A urine-based biomarker for chronic prostatitis/chronic pelvic pain syndrome: a retrospective multi-center study[J]. Translational Andrology and Urology,2020,9(5).通讯作者

[5]Zhang Kaishu,FuLonglong,AnQi,HuWeihong,LiuJianxin,TangXiuming,DingYu,LuWenhong,LiangXiaowei,ShangXuejun,GuYiqun. Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia.[J]. BMC complementary medicine and therapies,2020,20(1).通讯作者

[6]CaiHongcai,QingXingrong,Niringiyumukiza Jean Damascene,ZhanXuxin,MoDunsheng,ZhouYuanzhong,ShangXuejun. CFTR Variants and Renal Abnormalities in Males With Congenital Unilateral Absence of the Vas Deferens (CUAVD):A Systematic Review and Meta-analysis of Observational Studies[J]. Obstetrical & Gynecological Survey,2019,74(9).通讯作者

[7]Yu Lisha,YangXiaojing,MaBo,YingHanjie,ShangXuejun,HeBingfang,Zhang Qi. Abnormal arachidonic acid metabolic network may reduce sperm motility via P38 MAPK.[J]. Open biology,2019,9(4).通讯作者

[8]Lv Bi-Hua,TanWei,Zhu Chang-Cai,ShangXuejun,Zhang Ling. Properties of a Stable and Sustained-Release Formulation of Recombinant Human Parathyroid Hormone (rhPTH) with Chitosan and Silk Fibroin Microparticles.[J]. Medical science monitor : international medical journal of experimental and clinical research,2018,24.通讯作者

近5年主要研究课题如下：

1基于内外暴露监测的环境和行为因素对胚胎发育与妊娠影响研究，国家重点研发计划，项目编号2018YFC1004300（2018.18-2022.12），在研，项目负责人。

2电生理适宜技术在男科疾病防治的应用，国家科技计划项目（2021），项目编号HDSL202001049（2021.06-2023.06），在研，合作单位负责人。

3炎症抑制FABP9/12导致脂肪酸代谢障碍影响精子发生的机制研究，国家自然科学基金，项目编号81771646（2018.01-2021.12），结题，主持。

4左卡尼汀在脂多糖有到达数脂肪酸代谢紊乱导致生精障碍中的保护机制研究，江苏省“六大人才高峰”项目，项目编号WSN-069（2018.01-2020.12），结题，主持。

5男性军人慢性前列腺炎与不育症精准诊疗研究及生育力保存机制探讨，军队计生专项研究任务计划，项目编号17JS013，结题，主持。