教育和工作经历：

2007年8至今 必赢76net线路讲师、副教授、教授

2013年11月—2014年11月，美国国立卫生院肿瘤研究中心 访学学者

2007年6月 获必赢76net线路理学博士学位

1997年6月 获南京医科大学临床医学学士学位

教学：

首批江苏省一流本科课程、必赢76net线路“百”层次优质课程《组织学和胚胎学》课程负责人和主讲教师，公选课《人工智能推动微观形态精准观察》、《人类生殖与胚胎发生》课程负责人。

研究生课程《生殖生物学》负责人，《组织病理学》和《疾病研究的生物学方法》等研究生课程主讲教师。

江苏省解剖学会 理事

江苏省解剖学会第十二届理事会组织胚胎学专业委员会 委员

江苏省高等学校医药教育研究会 理事

江苏省高等学校医药教育研究会-医学人文素质教育专业委员会 理事

江苏省医学会男科分会 委员

《中华男科学》杂志 编委

南京口腔医学会 副理事长

泌尿系肿瘤相关、环境毒理类、公共健康类SCI杂志审稿专家

2018年以来通讯作者论文：

37.    Xia Y, Chen Y, Chen J, Han X, Wang J, Li D. Gestational exposure to a fluorotelomer alcohol causes behavioral abnormalities by disrupting the blood–brain barrier in offspring. Environ Chem Lett (2024). https://doi.org/10.1007/s10311-024-01707-5

36. Chen J, Xia Y, Ben Y, Lu X, Dou K, Ding Y, Han X, Yang F, Wang J, Li D. Embryonic exposure to aluminum chloride blocks the onset of spermatogenesis through disturbing the dynamics of testicular tight junctions via upregulating Slc25a5 in offspring. Sci Total Environ.2024 Jan 17;915:170128.

35. Chen Y, Lu Y, Yang L, Ma W, Dong Y, Zhou S, Liu N, Gan W, Li D. LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner. J Exp Clin Cancer Res.2023 Sep 28;42(1):252.

34.Li L, Xia Y, Chen J, Han X, Hao L, Li D, Liu Y. DBP exposure induces thyroid inflammatory impairment through activating AKT/NF-κB/NLRP3 signaling. Ecotoxicol Environ Saf. 2023 Aug 23;264:115385. 

33. Xia Y, Hao L, Li Y, Li Y, Chen J, Li L, Han X, Liu Y, Wang X, Li D. Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice. Ecotoxicol Environ Saf. 2023 Jan 15;250:114497.

32.Ma T, Xia Y, Wang B, Yang F, Ding J, Wu J, Han X, Wang J, Li D. Environmentally relevant perinatal     exposure to DBP accelerated spermatogenesis by promoting the glycolipid metabolism of Sertoli cells in male offspring mice.Toxicol Lett. 2023 Mar 15;377:16-28.

31.Ma W, Li X, Yang L, Pan J, Chen Y, Lu Y, Dong X, Li D, Gan W. High VSX1 expression promotes the     aggressiveness of clear cell renal cell carcinoma by transcriptionally regulating FKBP10. J Transl Med.  2022 Dec 3;20(1):554. 

30. Yang L, Yin H, Chen Y, Pan C, Hang H, Lu Y, Ma W, Li X, Gan W, Guo H, Li D. Low expression of PEBP1P2 promotes metastasis of clear cell renal cell carcinoma by post-transcriptional regulation of PEBP1 and KLF13 mRNA. Exp Hematol Oncol. 2022 Nov 8;11(1):87.

29.Yang L, Chen Y, Liu N, Lu Y, Li X, Ma W, Gan W, Li D. 5mC and H3K9me3 of TRAF3IP2 promoter region accelerates the progression of translocation renal cell carcinoma. Biomark Res. 2022 Jul 27;10(1):54.

28.Liu N, Chen Y, Yang L, Shi Q, Lu Y, Ma W, Han X, Guo H, Li D, Gan W. Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma. Clin Transl Med. 2022 Apr;12(4):e797.

27.Chen Y, Yang L, Lu Y, Liu N, Ma W, Fan H, Hu Q, Han X, Gan W, Li D. Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11.2 translocation renal cell carcinoma. Cancer Lett. 2022 Jul 10;538:215689.

26.Xia Y, Chen J, Ma T, Meng X, Han X, Li D. Maternal DBP exposure promotes synaptic formation in offspring by activating astrocytes via the AKT/NF-κB/IL-6/JAK2/STAT3 signaling pathway. Sci Total Environ. 2022 Mar 8:154437.

25.Yang L, Chen Y, Liu N, Lu Y, Ma W, Yang Z, Gan W, Li D. CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3. Mol Cancer. 2022 Jan 18;21(1):23.

24.Shi Q, Liu N, Yang L, Chen Y, Lu Y, Guo H, Han X, Li D, Gan W. Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma. Cell Commun Signal. 2021 Nov 16;19(1):114.

23.Wang B, Yin X, Gan W, Pan F, Li S, Xiang Z, Han X, Li D. PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma. Autophagy. 2021 Sep;17(9):2475-2493.

22.Chen Y, Yang L, Liu N, Shi Q, Yin X, Han X, Gan W, Li D. NONO-TFE3 Fusion Promotes Aerobic Glycolysis and Angiogenesis by Targeting HIF1A in NONO-TFE3 Translocation Renal Cell Carcinoma. Curr Cancer Drug Targets. 2021;21(8):713-723.

21.Ma T, Zhou Y, Xia Y, Jin H, Wang B, Wu J, Ding J, Wang J, Yang F, Han X, Li D. Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice. Toxicology. 2021 Jul 16;459:152860.

20.Yang L, Chen Y, Liu N, Shi Q, Han X, Gan W, Li D. Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN. J Hematol Oncol. 2021 Mar 19;14(1):46.

19.Wang B, Gan W, Han X, Liu N, Ma T, Li D. The positive regulation loop between NRF1 and NONO-TFE3 fusion promotes phase separation and aggregation of NONO-TFE3 in NONO-TFE3 tRCC. Int J Biol Macromol. 2021 Feb 13; 176:437-447.

18.Shi Q, Liu N, Zhu Y, Qu F, Xu L, Li X, Zhang G, Guo H, Li D, Gan W. A new risk-scoring system to predict Xp11.2 translocation renal cell carcinoma in adults. J Int Med Res. 2021 Mar;49(3):300060521997661.

17.Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X. m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. Autophagy. 2021 Feb;17(2):457-475.

16.Zhang L, Meng X, Li D, Han X. piR-001773 and piR-017184 promote prostate cancer progression by interacting with PCDH9. Cell Signal. 2020 Dec;76:109780.

15.Zhu Y, Liu N, Guo W, Pu X, Guo H, Gan W, Li D. ALK rearrangement in TFE3-positive renal cell carcinoma: Alternative diagnostic option to exclude Xp11.2 translocation carcinoma. Pathol Res Pract. 2020 Dec;216(12):153286.

14.Liu N, Guo W, Shi Q, Zhuang W, Pu X, Chen S, Qu F, Xu L, Zhao X, Li X, Zhang G, Guo H, Gan W, Li D. The suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma. Sci Rep. 2020 Oct 1;10(1):16361.

13.Ma T, Zhou Y, Xia Y, Meng X, Jin H, Wang B, Chen Y, Qiu J, Wu J, Ding J, Han X, Li D. Maternal Exposure to Di-n-butyl Phthalate Promotes the Formation of Testicular Tight Junctions through Downregulation of NF-κB/COX-2/PGE2/MMP-2 in Mouse Offspring. Environ Sci Technol. 2020 Jul 7;54(13):8245-8258.

12.Ma T, Hou J, Zhou Y, Chen Y, Qiu J, Wu J, Ding J, Han X, Li D. Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2. Environ Health. 2020 Aug 1;19(1):87.

11.Meng X, Zhang L, Hou J, Ma T, Pan C, Zhou Y, Han R, Ding Y, Peng H, Xiang Z, Li D, Han X. The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice. Sci Total Environ. 2020 Sep 20; 736:139678.

10.Xia Y, Ma T, Ji J, Zhang L, Wang Y, Wu J, Ding J, Han X, Li D. In utero exposure to DBP stimulates release of GnRH by increasing the secretion of PGE2 in the astrocytes of the hypothalamus in the offspring mice. Ecotoxicol Environ Saf. 2020 Jul 15;198:110698.

9.Wang B, Gan W, Han X, Li D. PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission. Cell Biol Int. 2020 Aug;44(8):1727-1733.

8.Zhang L, Meng X, Pan C, Qu F, Gan W, Xiang Z, Han X, Li D. piR-31470 epigenetically suppresses the expression of glutathione S-transferase pi 1 in prostate cancer via DNA methylation. Cell Signal. 2020 Mar;67:109501.

7.Zhou Y, Ma T, Yan M, Meng X, Wu J, Ding J, Han X, Li D. Exposure of DBP in gestation induces inflammation of testicular Sertoli cells in progeny by activating NLRP3 inflammasomes. Sci Total Environ. 2020 Mar 10;707:136139.

6.Han R, Zhang L, Gan W, Fu K, Jiang K, Ding J, Wu J, Han X, Li D. piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine. Prostate. 2019 May;79(7):798-812.

5.Yin X, Wang B, Gan W, Zhuang W, Xiang Z, Han X, Li D. TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas. J Exp Clin Cancer Res. 2019 Mar 8;38(1):119.

4.Liu N, Gan W, Qu F, Wang Z, Zhuang W, Agizamhan S, Xu L, Yin J, Guo H, Li D. Does the Fuhrman or World Health Organization/International Society of Urological Pathology Grading System Apply to the Xp11.2 Translocation Renal Cell Carcinoma?: A 10-Year Single-Center Study. Am J Pathol. 2018 Apr;188(4):929-936.

3.Zhang L, Meng X, Xiang Z, Li D, Han X. From the Cover: Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis. Toxicol Sci. 2018 Jan 1;161(1):159-170.

2.Yin X, Ma T, Han R, Ding J, Zhang H, Han X, Li D. MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)-induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro. 2018 Mar;47:79-88.

1.Chen Y, Wang J, Pan C, Li D, Han X. Microcystin-leucine-arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cell Mol Life Sci. 2018 Mar;75(6):1117-1132.

国家自然科学基金面上项目（42477460）

国家自然科学基金面上项目（31971517）

国家自然科学基金面上项目（21377052）

国家自然科学基金青年项目（30800115）

江苏省自然科学基金（BK20221444）

江苏省自然科学基金（BK20131281）

江苏省自然科学基金（BK2010367）

江苏省第八批“六大人才高峰”高层次人才培养对象项目（卫生行业2011-WS070）

教育部新青年教师基金（200802841006）

必赢76net线路技术创新基金项目：Xp11.2易位型肾癌分子诊断模型的建立

生命分析化学国家重点实验室自主研究课题（5431ZZXM2004）：Xp11.2易位型肾癌分子诊断模型的建立

2023年 江苏省“优秀博士学位论文”指导教师

2023年 必赢76net线路“师德先进”团队——人体解剖与组织胚胎学科教师团队成员

2023年 必赢76net线路“优秀博士学位论文”指导教师

2022年 必赢76net线路“优秀博士学位论文”指导教师

2022年 必赢76net线路优秀教师

2020年 必赢76net线路优秀博士生导师

2020年 必赢76net线路“魅力导师奖”

2019年 江苏省高校微课教学比赛 三等奖

2018年 江苏省公司产品与研究成果奖（研究类）三等奖

2018年 必赢76net线路“魅力导师奖”

2017年 华东地区青年学者高峰论坛青年学者奖

2017年 必赢76net线路教学成果奖

2016年 必赢76net线路创新育人奖

2015年 必赢76net线路优秀教师