甘振继
教授
电话：025-58641546邮箱：ganzj@nju.edu.cn 地址：研究方向：

线粒体，骨骼肌，代谢疾病分子机制
  • 个人简介
  • 学术兼职
  • 代表性论文
  • 承担科研项目
  • 获奖情况

甘振继，必赢76net线路教授，博士生导师，国家杰青，国家优青，国家海外高层次人才，江苏省“双创”人才。曾获得美国心脏学会Louis and Arnold Katz Basic Science Award，中国生物物理学会代谢生物学分会“青年科学家奖”。博士毕业于中科院上海生命科学研究院，曾在美国Sanford-Burnham医学研究所从事科研工作，长期致力于骨骼肌的生理调控规律研究，取得系统性重要成果。以通讯作者在Nat Cell Biol.、Sci Transl Med.、J Clin Invest.、J Exp Med.、Nat Commun.、Sci Adv.、PNAS.等主流学术期刊发表研究论文20余篇，并受邀在Cell Res.撰写相关综述。研究成果为加深理解骨骼肌稳态调节在代谢健康中的生理学作用和机制提供了新的理论线索，得到国内外同行的广泛关注和认可。

中国生物物理学会代谢生物学分会青年理事秘书长

中国病理生理学会内分泌与代谢分会副秘书长

中国细胞生物学学会细胞代谢分会理事

中国生物物理学会线粒体生物学分会理事

中国细胞生物学学会细胞结构与细胞行为分会理事

中国生化与分子生物学学会代谢分会理事

为Dev Cell.、J Clin Invest.、Nat Commun.、Cell Rep.、Cell Death Differ.、J Cachexia Sarcopenia Muscle.、Autophagy、Aging Cell、EMBO Rep、FASEB J. 等学术期刊审稿


代表性成果：

  1. Mao Y#, Jin Z#, Yang J, Xu D, Zhao L, Kiram A, Yin Y, Zhou D, Sun Z, Xiao L, Zhou Z, Yang L, Fu T, Xu Z, Jia Y, Chen X, Niu FN, Li X*, Zhu Z*, Gan Z*. Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse.Sci Transl Med. 16(750): eadk9811.

  2. Xiao L#, Yin Y#, Sun Z#, Liu J#, Jia Y, Yang L, Mao Y, Peng S, Xie Z, Fang L, Li J, Xie X* and Gan Z*.AMPK phosphorylation of FNIP1 (Ser220) controls mitochondrial function and muscle fuel utilization during exercise. Science Advances. 2024; 10(6): eadj2752. 

  3. Fu T #, Sun W#, Xue J#, Zhou Z#, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang XN, Wan Q, Lu B, Chen Y, Zhu MS, Philipp E. Scherer, Fang L, Piao HL, Shao M* and Gan Z*. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switch of adipocytes. Nat Cell Biol. 2023; doi: 10.1038/s41556-023-01155-3.

  4. Gan Z* and Shao M. Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover. Nat Cell Biol. 2023; doi: 10.1038/s41556-023-01161-5.

  5. Guo Q#, Xu Z#, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z*. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.Science Advances. 2022; 8(30): eabo0340.

  6. Yin Y, Xu D, Mao Y, Gan Z*. Comments on 'FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics'. J Mol Cell Biol. 2022; mjac033.

  7. Yin Y#, Xu D#, Mao Y#, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z*. FNIP1 regulates white adipose tissue browning and systemic glucose homeostasis by shaping intracellular calcium dynamics.J Exp Med. 2022; 219(5): e20212491.

  8. Xu Z#, Fu T#, Guo Q#, Zhou D, Sun W, Zhou Z, Chen X, Zhang Z, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu M, Fei W, Lu B, Gan Z*. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nat Commun. 2022; 13(1):894.

  9. He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z*and Liu Y*. IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay.J Clin Invest. 2021;131(17): e143737.

  10. Xiao L#, Liu J#, Sun Z#, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li J, Chen S, Xie X, Gan Z*. AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1.PLoS Genet.2021; 17(3): e1009488.

  11. Liu L#, Ding C#, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z*. Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest. 2020, 130(9):4710-4725.

  12. Liu L#, Cai J#, Wang H#, Liang X#, Zhou Q#, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*.Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis. Proc Natl Acad Sci USA. 2019; 116(24): 11776-11785.

  13. Xu Z, Fu T, Guo Q, Sun W, Gan Z*. Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.Pharmacol Res. 2018; 141:176-180.

  14. Gan Z*, Fu T, Kelly DP*, Vega RB*. Skeletal muscle mitochondrial remodeling in exercise and diseases. Cell Research. 2018; 28(10): 969-980.

  15. Fu T, Xu Z, Lin L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu M, Chen Q*, Gan Z*. Mitophagy directs muscle-adipose crosstalk to alleviate dietary obesity. Cell Reports. 2018; 23: 1357–1372.

  16. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega R, Zhu MS, Kelly DP, Gao X, Gan Z*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med.2016; 8(10):1212-1228. Cover story.

  17. Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Lai L, Kong Y, Xie H, Yi F, Lai L, Vega R, Kelly DP, Smith SR, Gan Z*. Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle. J. Biol. Chem.2016; 291(49):25306-25318.

  18. Liu J, Liang X, Gan Z*. Transcriptional regulatory circuits controlling muscle fiber type switching. Sci China Life Sci.2015; 58(4):321-7.

  19. Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013; 123(6):2564-75.

  20. Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP. The nuclear receptor PPARb/d programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev. 2011; 25(24):2619-30.

  21. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells. J Biol Chem.2006; 281(44):33386-94.


  1. 江苏省基础研究计划（自然科学基金），BK20140600，2014-2016、主持人，已结题;

  2. 国家“海外高层次青年人才”，2015-2017、主持人，已结题;

  3. 国家重点基础研究发展计划（973计划），2015CB856300，2015-2019、学术骨干，已结题;

  4. 国家自然科学基金面上项目，31471110，2015-2018、主持人，已结题;

  5. 国家自然科学青年科学基金，81400821，2015-2017、主持人、已结题;

  6. 江苏省双创计划-人才项目，2017-2019、主持人，已结题;

  7. 江苏省自然科学基金杰出青年基金项目，BK20170014，2017-2019、主持人，已结题;

  8. 国家自然科学基金面上项目，31771291，2018-2021、主持人，已结题;

  9. 国家自然科学基金重大研究计划，91857105，2019-2021、主持人，已结题;

  10. 国家重点研发计划，2018YFA0800704，2019-2024、课题组长，在研;

  11. 国家自然科学优秀青年科学基金，31922033，2020-2022、主持人，已结题;

  12. 江苏省“六大高峰人才”高层次人才项目，2019-2022、主持人，已结题;

  13. 国家重点研发计划，2022YFA0806003，2022-2027、课题骨干，在研;

  14. 国家自然科学杰出青年科学基金，32425019，2025-2029、主持人，在研。


美国心脏学会（AHA）博士后奖

美国心脏学会Katz基础研究青年学者奖(Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigator)

国家海外高层次人才项目入选者

江苏省“双创人才”

江苏省“杰出青年”

国家基金委“优青”

中国生物物理学会代谢生物学分会“青年科学家奖”

国家基金委“杰青