来源:必赢76net线路2022-09-22浏览次数:646

王宏宇

硕士研究生导师简介

姓名

王宏宇

研究方向:

糖脂代谢调控以及代谢综合症

联系方式

wanghy@nicemice.cn

学术兼职:



个人简介

王宏宇,2006年毕业于德国萨尔大学,获得博士学位。2006年至2010年,英国邓迪老员工科院细胞与发育生物学系,博士后;2010年至2010年,英国牛津老员工物化学系,助理研究员;2012年至2017年,必赢76net线路模式动物研究所,副研究员;2017年至今,必赢76net线路模式动物研究所,副教授。





代表性论文[5年通讯作者和第一作者]

  1. QuanC, Zhu SS, Wang RZ, Chen JM, Chen QL, Li M, Su S, Du Q, Liu MJ,Wang HY* and Chen S* (2022) Impaired SERCA2a phosphorylationcauses diabetic cardiomyopathy through impinging on cardiaccontractility and precursor protein processing. Life MetabolismDOI: 10.1093/lifemeta/loac013 (* corresponding authors)

  2. ZhuSS, Quan C, Wang RZ, Liang DR, Su S, Rong P, Zhou K, Yang XY,Chen QL, Li M, Du Q, Zhang JZ, Fang L, Wang HY* and Chen S*(2022) The RalGAPα1−RalA signal module protects cardiacfunction through regulating calcium homeostasis. Nat Commun 13:4278 DOI: 10.1038/s41467-022-31992-z (* corresponding authors)

  3. WeiW, Chen QL, Liu MJ, Sheng Y, OuYang Q, Feng WK, Yang XY, Ding LF,Su S, Zhang JZ, Fang L, Vidal-Puig A, Wang HY* and Chen S* (2022)TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun13: 3972 DOI: 10.1038/s41467-022-31735-0 (* correspondingauthors)

  4. YangXY, Chen QL, Ouyang Q, Rong P, Feng WK, Quan C, Li M, Jiang Q,Liang H, Zhao T-J, Wang H-Y and Chen S. Tissue-Specific Splicingand Dietary Interaction of a Mutant As160 Allele Determine MuscleMetabolic Fitness in Rodents. 2021 Diabetes Aug; 70(8):1826-1842.

  5. ChaoQ, Qian D, Min L, Wang R, Ouyang Q, Su S, Zhu S, Chen Q, Sheng Y,Chen L, Wang H, Campbell DG, MacKintosh C, Yang ZZ, Ouyang KF,Wang H-Y & Chen S. A PKB-SPEG signaling nexus links insulinresistance with diabetic cardiomyopathy by regulating calciumhomeostasis. 2020. Nature Comm. volume 11, Article number: 2186

  6. LiM, Quan C, Chen S, Wang H-Y. The 14-3-3 protein is an essentialcomponent of cyclic AMP signaling for regulation of chemotaxisand development in Dictyostelium.https://doi.org/10.1016/j.cellsig.2020.109739

  7. ChenQ, Rong P, Zhu S, Yang X, Ouyang Q, Wang HY, Chen S. (2019)Targeting RalGAPα1 in skeletal muscle to simultaneously improvepostprandial glucose and lipid control. Sci Adv. Apr 3; 5(4).doi: 10.1126/sciadv.aav4116.

  8. QuanC, Li M, Du Q, Chen Q, Wang H, Campbell DG, Fang L, Xue B,MacKintosh C, Gao X, Ouyang K, Wang HY, Chen S. (2019) SPEGControls Calcium Re-Uptake into the Sarcoplasmic ReticulumThrough Regulating SERCA2a by Its Second Kinase-Domain. Circ Res124(5): 712-726 doi: 10.1161/CIRCRESAHA.118.313916.

  9. ChenQ, Rong P, Xu DJ, Chen L, Xie B, Sheng Y, Li P, Wang HY* and ChenS*. (2017) Muscle-specific Rab8a deletion impairs lipid uptakeand storage in skeletal muscle and causes hyperlipidemia andhepatosteatosis in mice. Diabetes. 66(9):2387-2399.(*corresponding author)

  10. ChenL, Chen Q, Rong P, Wang HY* and Chen S*. (2017) The energysensing LKB1-AMPKα1 pathway regulates IGF1 secretion andconsequent activation of the IGF1R-PKB pathway in primaryhepatocytes. FEBS J. 2017 Jul; 284(13):2096-2109 (*correspondingauthor)





承担科研项目[项目负责人]

1.2021-2024,心血管、代谢性疾病等基因修饰动物模型研发,国家重点研发计划,2021YFF0702104240.00万元;

2.2019-2024,建立小鼠发育代谢表型库,国家重点研发计划,2018YFA0801104325.85万元;

3.2020-2023AS160-Arg684Ter突变及其与饮食互作在2型糖尿病发病中的作用与分子机制研究,国家自然基金(面上),3197106758.00万元;

4.2017-2020,胰岛素信号通路与糖尿病性心肌病发病机理的研究,国家自然基金(面上),3167145660.00万元;

5.2016-2019RalGAP在葡萄糖代谢稳态调控中的功能及作用机理研究,江苏省自然基金(面上),BK2016139310.00万元;


获奖情况