陈迪

姓名

陈迪

研究方向：

衰老生物学

联系方式

chendi@nju.edu.cn

学术兼职：

中国老年学学会衰老与抗衰老科学委员会委员

中国动物学会发育生物学专业委员会委员

Frontiers in Genetics期刊编委

Molecules and Cells期刊编委

Frontiers in Aging期刊编委

个人简介

2004年毕业于美国密苏里大学哥伦比亚分校，获哲学博士学位。2005-2012年间在美国巴克衰老研究所从事博士后和研究员工作。2013年至今在必赢76net线路任副教授。长期从事以秀丽隐杆线虫（C. elegans）为模式的发育和衰老生物学研究。主要研究方向包括:（1）Insulin/IGF-1和TOR信号通路组织特异性调控衰老的系统生物学研究；（2）饮食限制（dietary restriction）延缓衰老的分子机理；（3）RNA代谢调控衰老及其相关疾病的分子机制。

代表性论文[近5年通讯作者和第一作者]

1. Di Wu^#, Waijiao Cai^#, Xuan Zhang, Jianfeng Lan, Lina Zou, Samuel J. Chen, Zixing Wu, Di Chen*, Inhibition of PAR-1 Delays Aging via Activating AMPK in C. elegans. Aging, 2020, 12(24): 25700-25717. (^#, co-first authors)

2. Jianfeng Lan^#, Jarod A. Rollins^#, Xiao Zang^#, Di Wu^#, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi*, Aric N. Rogers*, Di Chen*, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019, 28(4): 1050-1062.e6. (^#, co-first authors)

3. Lina Zou, Di Wu, Xiao Zang, Zi Wang, Zixing Wu, Di Chen*, Construction of a Germline-specific RNAi tool in C. elegans. Scientific Reports, 2019, 9(1): 2354.

4. Lei Gao, Rujun Zhang, Jianfeng Lan, Ruonan Ning, Di Wu, Di Chen*, Weimin Zhao*, -Dihydroagarofuran-type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-extending Effects on the Nematode Caenorhabditis elegans. Journal of Natural Products, 2016, 79(12): 3039-3046.

5. Lei Hou^#, Dan Wang^#, Di Chen^#, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, William B. Mair, Jing-Dong J. Han, A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 23(3): 529-540. (^#, co-first authors)

6. Jianfeng Lan, Xuan Zhang, Di Chen*, Molecular Mechanisms of Dietary Restriction in Aging - Insights from Caenorhabditis elegans Research, Science China Life Sciences, 2015, 58(4): 352-358.

7. Di Chen*, Jiuli Zhang, Justin Minnerly, Tiffany Kaul, Donald L. Riddle, Kailiang Jia*, daf-31 Encodes the Catalytic Subunit of N alpha-Acetyl Transferase that Regulates Caenorhabditis elegans Development, Metabolism and Adult Lifespan, PLoS Genetics, 2014, 10(10): e1004699.

8. Di Chen*, Patrick Wai-Lun Li, Benjamin A. Goldstein, Waijiao Cai, Emma Lynn Thomas, Fen Chen, Alan E. Hubbard, Simon Melov, Pankaj Kapahi*, Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans, Cell Reports, 2013, 5(6): 1600-1610.

承担科研项目[项目负责人]

在研项目：

1. 2022-2025，细胞色素C调控秀丽隐杆线虫衰老的分子机制研究，国家自然科学基金委面上项目，32171156，58万元。

2. 2021-2026，果蝇和线虫发育代谢资源库的系统构建与分析，科技部国家重点研发计划，子课题，2021YFA0805802，120.86万元。

3. 2020-2023，秀丽线虫神经系统通过mRNA可变剪接调控衰老的分子机制研究，国家自然科学基金委面上项目，31971092，58万元。

获奖情况