工作简历
2002.8-2006.8 南京鼓楼医院普通外科 住院医师 2006.9-2012.9 南京鼓楼医院普通外科 主治医师 2012.10-2018.12 南京鼓楼医院普通外科 副主任医师 2012. 6-至今 必赢76net线路硕士研究生导师 2017. 6-至今 必赢76net线路博士研究生导师 2019.1-至今 南京鼓楼医院普通外科 主任医师 2019.7-至今 必赢76net线路教授 研修经历 2007.9-2008.3 香港大学外科学系肝脏疾病研究中心研修 2011.7－2012.8 美国MUSC移植中心研修 2017.8－2017.9 韩国ASAN医院肝移植中心研修 科研情况简介
必赢76net线路、南京医科大学博士／硕士生导师，国内外多家杂志的评审专家。主持国家自然基金2项，国家青年基金1项，省部级重点人才项目2项，省重点研发计划1项，江苏省十三五兴卫工程重点人才、六大人才高峰等省级科研项目4项。先后获得省部级科技进步奖4项。在国内外高水平学术刊物发表论文70余篇，其中第一或通讯作者SCI论文30余篇，累积影响因子总计100分，他引次数总计400余次，H-Index:12。 旨在进一步研究肝癌代谢与转移、代谢相关诊断标记物，并研发针对性的生物治疗手段（如溶瘤病毒）及其临床转化。在肝脏外科技术研究方面，临床主要围绕肝癌开展以手术为主的综合治疗，包括腹腔镜肝切除、肝移植等；首次提出腹腔镜肝癌背侧入路指导手术治疗，自行研发肝脏直线切割器和肝门阻断带。肝癌样本库的逐步建立，为肝癌生物标志物的筛选及治疗等方面的奠定基础。 研究内容
肝癌相关肿瘤代谢 肝癌生物治疗研究 肝脏外科微创技术
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Hu Y, Shi J, Wang S, Zhang W, Sun X, Sun B, Yu D. Laennec's approach for laparoscopic anatomic hepatectomy based on Laennec's capsule. BMC Gastroenterol. 2019 Nov 21;19(1):194. doi: 10.1186/s12876-019-1107-9. PubMed PMID: 31752706. Sun Q, Zhang Z, Lu Y, Liu Q, Xu X, Xu J, Liu Y, Yu H, Yu D, Sun B. Loss of Xanthine Oxidoreductase Potentiates Propagation of Hepatocellular Carcinoma Stem Cells. Hepatology. 2019 Oct 3. doi: 10.1002/hep.30978. [Epub ahead of print] PubMed PMID: 31578733. Meng G, Fei Z, Fang M, Li B, Chen A, Xu C, Xia M, Yu D, Wei J. Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma. Mol Ther Oncolytics. 2019 Mar 27;13:22-34. doi: 10.1016/j.omto.2019.03.004. eCollection 2019 Jun 28. PubMed PMID: 31011625; PubMed Central PMCID: PMC6461577. Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D. Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway. EBioMedicine. 2019 Jan;39:239-254. Yu DC, Wu XY, Sun XT, Ding YT. Glissonian approach combined with major hepatic vein first for laparoscopic anatomic hepatectomy. Hepatobiliary Pancreat Dis Int. 2018 Aug;17(4):316-322. Li B, Xu T, Liu C, Meng G, Sun Y, Qian L, Wang S, Wei J, Yu D, Ding Y. Liver-enriched Genes are Associated with the Prognosis of Patients with Hepatocellular Carcinoma. Sci Rep. 2018 Jul 25;8(1):11197. Li B, Feng W, Luo O, Xu T, Cao Y, Wu H, Yu D, Ding Y. Development and Validation of a Three-gene Prognostic Signature for Patients with Hepatocellular Carcinoma. Sci Rep. 2017 Jul 17;7(1):5517. doi: 10.1038/s41598-017-04811-5.PubMed PMID: 28717245; PubMed Central PMCID: PMC5514049. Dong G, Mao Q, Yu D, Zhang Y, Qiu M, Dong G, Chen Q, Xia W, Wang J, Xu L, Jiang F. Integrative analysis of copy number and transcriptional expression profiles in esophageal cancer to identify a novel driver gene for therapy. Sci Rep. 2017 Feb 7;7:42060. doi: 10.1038/srep42060. PubMed PMID: 28169357; PubMed Central PMCID: PMC5294420. (co-first author) Su L, Zhang H, Yan C, Chen A, Meng G, Wei J, Yu D, Ding Y. Superior anti-tumor efficacy of diisopropylamine dichloroacetate compared with dichloroacetate in a subcutaneous transplantation breast tumor model. Oncotarget. 2016 Oct 4;7(40):65721-65731. doi: 10.18632/oncotarget.11609. PubMed PMID: 27582548; PubMed Central PMCID: PMC5323187. Wei Ge, Yi Wang, Ya-Juan Cao, Min Xie, Yi-Tao Ding, Ming Zhang, De-Cai Yu. Radiological score for hemorrhage
in the patients with portal hypertension. Int J Clin Exp Pathol 2015;8(9): 11517-23 Yu D, Shi X, Meng G, Chen J, Yan C, Jiang Y, Wei J, Ding Y. Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma. Oncotarget. 2015 Apr 10;6(10):7619-31. PubMed PMID: 25844758; PubMed Central PMCID: PMC4480704. Ge W, Yu DC, Chen J, Shi XB, Su L, Ye Q, Ding YT. Lymphocele: a clinical analysis of 19 cases. Int J Clin Exp Med. 2015 May 15;8(5):7342-50. eCollection 2015. PubMed PMID: 26221274; PubMed Central PMCID: PMC4509219.
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